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FIGURE 1 Mitochondrial ISC biogenesis has two functions: (1) to synthesize functional clusters in the mitochondria, and (2) to provide an essential precursor to the CIA pathway via the inner membrane exporter ABCB7 (Lill et al., 2015)

c Stress-induced changes in H 2 O 2 and NO levels as well as antioxidant enzyme activities (general tendency)

2.3 PBPK model validation 2.3.1 PBPK model validation: PK simulations for S-CIT To validate the developed PBPK model of S-CIT, eleven clinical datasets (seven single-dose studies and four multiple-dose studies) were used

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